Calcium Signaling: Pyruvate and CRAC Meet at the Crossroads
نویسنده
چکیده
Receptor-evoked Ca(2+) influx is mediated by store-operated Ca(2+) channels, such as the CRAC channel, which mediates the I(crac) current. Recent work reveals that pyruvate, the precursor substrate for the Krebs cycle, regulates I(crac) to prolong Ca(2+) influx into the cell, thereby coupling oxidation of glucose and its own metabolism in the mitochondria to Ca(2+) influx by the CRAC channel.
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ورودعنوان ژورنال:
- Current Biology
دوره 17 شماره
صفحات -
تاریخ انتشار 2007